Tooth infections can make us downright miserable. The constant pain, swelling, and the throbbing that never seems to stop is enough to make anyone desperate for relief.
In this guide, we’ll recommend some of the strongest natural antibiotic that have been used for centuries to fight tooth infection, reduce inflammation, and soothe discomfort. But remember, these remedies are not cures—they’re a stopgap to help you manage the symptoms until you can get to your dentist.
Natural remedies can provide some temporary relief in the meantime, but it’s critical to see a dentist for professional care as soon as possible.

The Common Causes of Tooth Infection
Before diving into natural remedies, it’s important to understand that tooth infections don’t just happen overnight. They are the result of poor oral hygiene or neglected dental problems that have gone unchecked. Here are some of the most common causes:
- Cavities: One of the most common causes of tooth infections is untreated cavities. When cavities aren’t filled, bacteria can invade the inner layers of the tooth, leading to an infection.
- Gum Disease (gingivitis or periodontitis): Infected or inflamed gums can cause the gums to recede, leaving the tooth’s root exposed and vulnerable to infection. If not treated, it can lead to abscesses and severe pain.
- Previous Dental Work: If you’ve had a filling or crown in the past, these areas can be more susceptible to infection if not properly cared for.
- Trauma: A cracked or chipped tooth can expose the inside of the tooth to bacteria, causing an infection.
- Poor Diet and Smoking: A diet high in sugary foods and drinks, combined with smoking, can increase the chances of developing tooth infections by weakening the body’s immune system and encouraging bacterial growth.
Symptoms of a Tooth Infection
- Throbbing pain in or around the tooth
- Swelling in the face or neck
- Fever and chills
- A bad taste in your mouth or foul-smelling breath
- Sensitivity to hot and cold temperatures
- Pus or drainage around the tooth or gum area
How a Tooth Infection Ended up in Chronic Fatigue and Brain Fog
John, a 38-year-old man, had been struggling with intense fatigue and brain fog for years. Despite undergoing numerous tests with multiple specialists, he couldn’t find any clear answers. His heart was fine, his blood tests showed no abnormalities, and he didn’t have conditions like Epstein-Barr or sleep apnea.
After years of trying to figure out the cause of his symptoms, John visited an oral surgeon who made a surprising discovery: a longstanding infected tooth that had been left untreated for years. The oral surgeon explained that the infection had essentially “burned through” the tooth and was draining into his bloodstream. Thankfully, the infection hadn’t reached his sinus cavity yet, but it was still wreaking havoc on his health.
The surgeon explained that the bacteria in the infected tooth were producing neurotoxic toxins that could potentially explain John’s chronic fatigue and brain fog. This was a major revelation for John—his GP had run numerous tests, but never pointed to an infection. His white blood cell count and other markers were normal, and he had never noticed a change in his symptoms when prescribed antibiotics for unrelated conditions.
Now, with the surgery scheduled to remove the infected tooth, the oral surgeon was optimistic that John would start feeling much better—potentially even “like new.” John is hopeful, but also cautious, as he’s aware that recovery might take time and that his fatigue and brain fog may not vanish immediately after the surgery.
While these dental abscesses, can be extremely painful, it’s important to remember that they can be prevented or treated with prompt care.
The 12 of the Strongest Natural Antibiotic and Remedies for Tooth Infection
Here are twelve of the most effective and strongest natural antibiotic and remedies to fight tooth infection while you wait for your appointment.
Note that natural remedies can help reduce pain and fight bacteria temporarily, but they won’t replace professional dental care.
1. Garlic
Garlic has long been celebrated for its potent antibacterial properties, primarily due to allicin, a compound known for fighting off bacteria and promoting healing. Studies have demonstrated that allicin can effectively combat common oral pathogens that contribute to tooth infections. According to research published in the Journal of Research in Dental and Maxillofacial Sciences, garlic exhibits antimicrobial activity against a wide range of bacteria, including those responsible for oral infections.

How to Use It:
- Crush or finely chop a garlic clove and let it sit for a few minutes to activate the allicin.
- Place the crushed garlic directly on the infected tooth and gums for a few minutes.
- Alternatively, you can chew on a raw garlic clove for a few minutes if you’re able to tolerate it.
2. Clove Oil
Clove oil has been used for centuries as a natural pain reliever and infection fighter, thanks to eugenol, a compound that not only numbs the pain but also exhibits antibacterial properties. Studies have confirmed that clove oil is highly effective for treating oral infections.

How to Use It:
- Dilute a few drops of clove oil with a carrier oil (like coconut oil) and apply it directly to the infected area.
- You can also use a clove oil mouth rinse by adding a few drops of clove oil to warm water and swishing it around.
3. Oregano Oil
Oregano oil is well-known for its antimicrobial and anti-inflammatory effects. Studies have confirmed its ability to reduce oral bacteria and inflammation, which is crucial when dealing with infections in the mouth. According to a study published in National Library of Medicine, oregano oil has strong antimicrobial properties, particularly against bacteria that cause oral infections.
How to Use It:
- Dilute 1–2 drops of oregano oil in a tablespoon of carrier oil (such as olive or coconut oil) and apply it to the infected area.
- You can also add a few drops to warm water and use it as a mouth rinse.
4. Turmeric
Turmeric, particularly its active compound curcumin, is widely recognized for its powerful antibacterial and anti-inflammatory properties. Research has shown that turmeric can effectively reduce swelling and fight infection in the gums. A study in the Journal of Indian Society of Periodontology found that turmeric’s curcumin helps reduce inflammation and control oral bacteria, making it a valuable home remedy for gum health and infection prevention.

How to Use It:
- Make a paste by mixing turmeric powder with a small amount of water and apply it to the infected area.
- Alternatively, mix turmeric powder with coconut oil and use it as a natural mouthwash.
5. Peppermint Oil
Peppermint oil’s cooling effect can provide relief from inflamed gums while its antibacterial properties work to combat the infection. Studies have shown that peppermint oil is effective in managing oral infections. A review published in Molecules highlighted peppermint oil’s efficacy in reducing bacterial growth in the mouth, making it an ideal option for treating gum inflammation and infection.
How to Use It:
- Add a few drops of peppermint oil to a glass of warm water and use it as a mouth rinse.
- For localized pain relief, dilute a few drops of peppermint oil with a carrier oil and massage it around the affected area.
6. Apple Cider Vinegar
Apple cider vinegar (ACV) is well-known for its ability to fight bacteria and help balance pH in the mouth, although it should be used cautiously due to its acidic nature. While research on its direct impact on abscessed tooth is limited, studies suggest that diluted ACV may help reduce oral bacteria. A study in the Journal of Clinical Dentistry found that vinegar, when used in moderation, could help reduce bacterial load in the mouth.

How to Use It:
- Dilute one tablespoon of ACV in a glass of water and swish it around your mouth for 30 seconds.
- You can also add a bit of honey for its additional antibacterial effects.
7. Salt Water Rinse
Salt water has been a staple for oral hygiene for centuries due to its ability to reduce swelling and kill bacteria naturally. Numerous studies have shown that salt water rinses are effective at reducing oral bacteria and promoting gum health. In particular, a study published in International Journal of Dentistry found that salt water is highly effective in managing gum health and fighting infections in the mouth.

How to Use It:
- Dissolve half a teaspoon of salt in warm water and swish it around in your mouth for 30 seconds to a minute.
- Repeat this several times a day, especially after meals.
8. Aloe Vera
Aloe vera, known for its soothing properties, also possesses antibacterial effects that can help reduce inflammation and promote healing in the gums. Research shows that aloe vera can aid in reducing plaque and preventing gum disease. A study published in the Journal of Indian Society of Periodontology found that aloe vera gel can help manage gum inflammation and oral infections, making it an effective natural remedy for oral health.

How to Use It:
- Apply aloe vera gel directly to the infected area on your gums.
- Alternatively, you can use aloe vera juice as a mouth rinse.
9. Guava Leaves
Guava leaves are packed with antibacterial and anti-inflammatory properties, which have been found to be effective in treating oral infections. A study in Food and Chemical Toxicology confirmed that guava leaf extract significantly reduced bacteria in the mouth, making it an effective natural remedy for oral health.

How to Use It:
- Boil guava leaves in water for about 10 minutes, then use the water as a mouth rinse.
- You can also chew on fresh guava leaves for relief.
10. Hydrogen Peroxide
Hydrogen peroxide, often used for wound cleaning, is also effective in reducing bacteria and promoting oral health when diluted properly. Studies show that hydrogen peroxide can effectively kill bacteria in the mouth and help with gum healing. A study in The Journal of Periodontology highlighted hydrogen peroxide’s effectiveness in reducing bacterial loads and supporting gum health.
How to Use It:
- Mix equal parts hydrogen peroxide (3%) and water and use it as a mouth rinse for 30 seconds.
- Do not swallow the solution, and avoid using it too frequently, as it can cause irritation.
11. Oil Pulling
Oil pulling is an ancient Ayurvedic practice where oil (typically coconut oil) is swished around the mouth to pull toxins and bacteria from the gums and teeth. Numerous studies have shown its benefits in reducing plaque and bacteria. A systematic review published in the Journal of Clinical and Diagnostic Research concluded that oil pulling with coconut oil is effective in reducing oral bacteria and improving gum health.
How to Use It:
- Swish one tablespoon of coconut oil around your mouth for 15–20 minutes, then spit it out and rinse with warm water.
12. Tea Tree Oil
Tea tree oil is a powerful natural antibiotic oil that can help reduce infections without damaging the gums when used properly. A study in Complementary Therapies in Medicine showed that tea tree oil has strong antimicrobial properties and can be used to reduce bacteria in the mouth without causing irritation or harm to oral tissues.
How to Use It:
- Dilute a few drops of tea tree oil with water and use it as a mouthwash.
- Apply diluted tea tree oil to the infected area using a cotton ball.
How Do These Natural Remedies Actually Work?
Can garlic, cloves, or oil pulling really help you with a tooth infection? Natural antibiotics and remedies for tooth infections don’t work by magic—they rely on science.
While many natural remedies have been used for centuries, it’s only in recent years that scientists have caught up to explain why they are so effective in combating tooth infections. Let’s understand the chemistry and biology behind the most common active ingredients, so you can feel more confident about using them:
- Allicin, present in garlic, is a powerful compound with antibacterial properties. Allicin disrupts bacterial cell membranes, killing harmful bacteria and preventing infection. Studies have shown it can fight oral pathogens and promote healing in the mouth.
- Eugenol present in clove oil has pain-relieving and antibacterial effects. It numbs the pain and reduces inflammation, while also fighting bacteria in the infected area. Eugenol has been shown to inhibit oral pathogens and help heal gum tissue.
- Carvacrol, present in oregano oil, is a compound that targets bacterial cell walls, breaking them down. This helps eliminate harmful bacteria causing toothache while also reducing gum inflammation. Carvacrol is particularly effective against bacteria like Streptococcus mutans.
- Curcumin in turmeric has strong anti-inflammatory properties that help reduce gum swelling and pain. It blocks inflammatory molecules and promotes healing. Research has shown that curcumin can improve oral health and reduce infection symptoms.
- Eugenol and menthol in peppermint oil fight infection and relieve pain. Menthol provides a cooling sensation that numbs the pain, while eugenol fights bacteria and reduces inflammation in the gums, making it an effective remedy for tooth infections.
- Acetic acid in apple cider vinegar helps balance the mouth’s pH and prevents bacteria from thriving. Its acidity neutralizes harmful microbes, reducing the risk of further infection. However, it should be diluted to protect tooth enamel from damage.
What to Do When Natural Remedies Aren’t Enough
Natural cures aren’t a permanent solution. There are limits to what these treatments can do.
If the pain becomes unbearable or if the swelling spreads to your face or neck, it could be a sign of a more serious infection, such as an abscess. At this point, it’s time to get professional care to drain the infection and possibly prescribe antibiotics.
If you have a fever is your body’s way of telling you that an infection has spread beyond the tooth and may be affecting your body systemically. This is a clear sign that the infection needs to be addressed by a dentist or doctor.
Natural remedies may reduce pain and inflammation, but only a dentist can fully treat the infection, whether through antibiotics, drainage, or more advanced dental treatments.
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